New noninvasive tests may help pediatric heart recipients

Nathan Kahl — Thu, 15 Feb 2024 15:08:18 +0000

New noninvasive tests may help pediatric heart recipients Nathan Kahl Thu, 02/15/2024 - 10:08

Each year, approximately 500 children in the U.S. undergo heart transplantation. These children face considerable stress.

Undergoing a biopsy—an invasive procedure using a catheter to remove a piece of the transplanted heart to test it—is just one way such patients are poked and prodded. Cardiac biopsies are a necessary evil, serving as the primary way doctors detect if a heart is likely to be rejected. But now George Mason University and the Inova Health System are teaming up to develop ways to make that determination with noninvasive techniques.

Jason Goldberg. Photo provided

“On average, children pediatric heart transplant patients undergo approximately 10 biopsies within the first year of transplant…and more if they have rejection,” said Jason Goldberg, MD, MS, a pediatric cardiologist and research fellow at Mason. “That's a big deal, especially since taking a child to the hospital is no small thing. They have to go under anesthesia, they have to have needles stuck in them. It's quite traumatic, and diagnosing rejection in a noninvasive manner may help start treatment before the patient is sick and not feeling well.”

Cardiologist Palak Shah, MD, an adult heart-transplant specialist who serves as Goldberg’s research mentor at Inova, has worked with colleagues both at Inova and Mason to evaluate the potential of microRNA (miR) to provide clues on whether heart transplant recipients are at risk for rejection. miR are small, noncoding RNA molecules that impact the regulation of gene-expression.

Shah and his team published a paper in 2022 that was cause for optimism. The researchers found that “miRs are promising genomic biomarkers in cardiovascular medicine, have the potential ability to detect heart transplant rejection, and may provide mechanistic insights into molecular pathways modulated during rejection.”

“MicroRNA is a type of transcription factor, which is a protein that turns specific genes ‘on’ or ‘off’ by binding to nearby DNA,” explained Goldberg. “And it's encoded to a certain degree to do what the body needs, so when you measure the microRNA, you can get a sense of what the body is doing—essentially it's a molecular biomarker. What Palak and others found is that there are microRNA signatures correlating with heart transplant rejection.”

Goldberg is now using the technique to test children who have received new hearts. He and his colleagues at Mason and Inova received a grant from the Enduring Hearts Foundation, which includes collaboration with colleagues at the University of Pittsburgh Medical Center who have bio-banked blood samples taken at the time of biopsy. The biomarkers are validated by looking simultaneously at the microRNA taken at the same time as a rejection or nonrejection biopsy.

Testing microRNA allows doctors to determine the likelihood of a successful heart transplantation

The new pediatric developments are being supported by a partnership between Inova and the Mason Statistics Collaboration Core (SCC), which is providing the mircoRNA analysis. This and other collaborative projects require machine learning and other advanced statistical techniques utilized by Mason faculty and graduate students.

Goldberg said that the collaboration is mutually beneficial. “Mason has great research and science but no medical school, whereas Inova has great medicine but lacks significant biomedical academic partnership," said Goldberg. "With the two organizations working together it creates a lot of runway for research.”

Goldberg is one the first members of a postdoc program for Inova clinician-scientists interested in developing skills in statistics and data science. “I'm a pediatric heart transplant physician and I've been taking care of patients for nearly 15 years,” he said. “But I was at a point in my career where I really caught the research bug, and it hasn’t gone away."

Palak, Goldberg's mentor, has ongoing collaborations with Jiayang Sun, chair of Mason's Department of Statistics, and Carolyn Drews-Botsch, chair of the Department of Global and Community Health in Mason's College of Public Health. Sun is the Mason PI and Drews-Botsch is the Co-PI for this special joint postdoc program with Inova Health System.

“This pioneering program between Mason and Inova uniquely trains the next generation of medical research scientists in collaborative research and some essentials in data science, statistics, or epidemiology to address the challenges of the AI and information revolution," said Sun. The program features dedicated mentors from Mason in the fields of statistics, epidemiology, and global health, along with top physicians and researchers at Inova.

Goldberg is enthused about the new development, and most importantly, the increased longevity it may bring to young patients with critical heart disease. “When I was in my cardiology fellowship, we thought that the big change in heart transplantation would be that we wouldn't have to do it anymore, that there would be stem cells and other fancy machines that wouldn't require the use of donor organs. But time and time again, nothing has really worked to replace heart transplantation.

“It has become clear that the next frontier for our patients includes personalized medicine where molecular biomarkers and therapies can evaluate ongoing pathology and define specific treatments before significant illness develops. I am proud to be part of this work at Mason and Inova.”

In This Story

Jiayang Sun

Carolyn Drews-Botsch, PhD, MPH

Topics

Statistics Collaboration Core

Research

College of Public Health

College of Engineering and Computing

CEC faculty research

Joint postdoc program develops from partnership between Statistics Department, Inova Health

Teresa Donnellan — Thu, 28 Sep 2023 18:42:25 +0000

Joint postdoc program develops from partnership between Statistics Department, Inova Health Teresa Donnellan Thu, 09/28/2023 - 14:42

In This Story

Jiayang Sun

A partnership between George Mason University’s Statistics Department and Inova Health Care Services has entered its fifth year and continues to grow. The partnership has motivated a new initiative: a postdoc program for Inova researchers interested in developing skills in statistics and data science, run jointly by George Mason’s statistics and global and community health departments. Mohamad Bahij Moumneh, MD, and Jason F. Goldberg, MD, are the program’s standing inaugural members.

“As a fresh Lebanese medical graduate interested in expanding his acquired skills in the field of research, especially cardiology, and academia, the joint program provided me with this golden opportunity,” said Moumneh. He added, “By maximizing the resources of each institute, enhancements in the overall picture and quality of research and healthcare education occur, and allow both institutions to keep, if not exceed, pace with novel technologies and healthcare advancements and institutions.”

The partnership between Mason Statistics and Inova Health was supported by a contract between the university and the healthcare system via a parent award from NIH to the iTHRIV partnership. It supported the experts in George Mason’s Statistics Collaboration Core (SCC) to work with colleagues from Inova Health Care Services on research projects involving statistics or data science. To initialize each new project, INOVA researchers visit statinova.gmu.edu.

“The Statistics Collaboration Core (SCC) is a collaboration platform that supports and facilitates statistical collaborations with internal and external investigators or seekers for evidenced-based research, or statistical, biostatistical, or data science support to decision-making,” explained Jiayang Sun of Mason’s statistics department. Sun is a Principal Investigator on the new grant establishing the postdoc program, alongside co-PI Carolyn Drews-Botsch, the chair of the department of global and community health in Mason’s School of Public Health.

“The partnership between Inova and Mason will help with our research efforts aimed at prolonging life after heart transplantation,” said Goldberg. He noted that, for his case, SCC has provided advanced analysis of mircoRNA clinical rejection scores and has used machine learning to evaluate risk modeling of adverse outcomes within the first year of heart transplantation.

“These collaborations will continue to produce meaningful cardiovascular research,” he said.

Of the five-year partnership between Mason Statistics and Inova Health, Sun noted the relationship has been fruitful, producing additional grants, publications in the health and medical sector, and new grant proposals. She added that it serves as a welcome opportunity for both tenure track and term faculty to perform original research and collaborate with colleagues dealing with real-world problems. Research projects from the partnership have covered such important topics as opioid use, sepsis, heart failure, and—before there were reliable tests—the spread of COVID-19 among children in northern Virginia.

Sun, Moumneh, and Goldberg are likewise optimistic about the new joint postdoc program.

“Researchers can collaborate on various projects that eventually might lead to medical breakthroughs. One could say that the joint program fosters an environment of innovation and growth. The joint program also allows the addressing of pressing healthcare dilemmas, an event that might encourage students to think of possible solutions and managements,” said Moumneh.

Topics

Statistics

Inova

Department of Statistics

College of Public Health

College of Engineering and Computing

School of Computing

Community Partners

Students